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Laminins are a kind of proteins that are found in the lamina and are called the basement membrane. This is a very basic protein network that forms the foundation for many cells and organs. Laminins are very important and they are an active part of the lamina. They differentiate cells, and help in migration and adhesion and their very survival. |
The laminin molecules are very similar to the DNA molecules and they form a vine shaped structure. They are also named after the chain composition they are found in. they are trimetric proteins and they contain three chains, the alpha chain, the gamma chain and the beta chain. They are found in three, five and three genetic variants. The chain of the laminin matters to define it actually. For example, the laminin 511 has alpha 5, beta 1 and gamma 1 chains. Scientists have identified fourteen different variations in chains.
The trimetric proteins form a cross over pattern that can easily bind into the cell membrane and also in extra cellular matrix molecules. The laminins structure is found in every living organism. It is found in every single issue of the organism in fact. Laminin’s main function is in the maintenance of the tissue. If there are any defective laminins present they might cause muscular dysfunctions and also hamper their growth. They are one of the reasons for disabilities like muscular dystrophy. It can also cause a skin blistering disease that becomes fatal. Defective laminas also affect the kidneys and cause nephritic syndrome.
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